Disrupted self in Alzheimer's disease: Beyond midline structures: Commentary on Wong et al.
نویسندگان
چکیده
Midline structures of the brain are thought to be essential to self-related processes. In particular, medial prefrontal cortex (MPFC) and anterior cingulate cortex (ACC) play a crucial role in the self concept. This hypothesis mainly comes from the wealth of PET and fMRI studies showing activations in ventral MPFC/ACC during judgment with self-reference in healthy people (D'Argembeau et al., 2005; Northoff et al., 2006). Subsequent studies have further suggested that the ventral MPFC/ACC should be activated when “crystallized” aspects of the self (i.e. self concept/conceptual self) are engaged (Martinelli et al., 2012). In patients with Alzheimer’s disease (AD), one can assume that altered self reference effect (SRE), i.e. the absence of memory advantage for information that has been previously linked to the self at encoding, can be related to functional or structural perturbations of a conceptual self or “core self”. However, this hypothesis has been challenged by a study showing that AD did activate MPFC during a traditional self reference task (Genon, Bahri, et al., 2014; Genon, Bastin, et al., 2014) and a recent replication by Gaubert et al. (2016). Accordingly, when Wong et al. (in press) searched for correlation between individual SRE and grey matter volume (GMV) variability specifically within midline structures, they did not find a significant specific role of the ventral MPFC/ACC in a mixed group of AD and healthy controls. Thus, many studies converge to show that altered SRE in AD is not directly related to local functional and/or structural damage to ventral MPFC/ACC.
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عنوان ژورنال:
- Cortex; a journal devoted to the study of the nervous system and behavior
دوره شماره
صفحات -
تاریخ انتشار 2017